Panajachel was founded by the Spanish in the 16th century after they and their Kaqchikel allies defeated the Tz'utujils. Following the Spanish conquest, Franciscans established a church and monastery on the lake, and the city of Panajachel grew around it. Today, “Pana” as it’s often called is one of the most popular tourist destinations in the country. Santander Street is the main tourist-centered thoroughfare, lined with handicraft stalls, bars, and restaurants. Calle Principal (Main Street) is more local-focused with the village market, and the striking 16th century Church of St. Francis of Asisi. Head down to the waterfront and you’ll see why the city and surrounding area is so popular. Soak in the spectacular panoramic views of the San Pedro, Tolimán and Atitlán volcanoes across the lake, or if you want to get your feet wet, rent a kayak or paddleboard.